%0 Journal Article
%T The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat
%J -
%D 2019
%R https://doi.org/10.1038/s41443-019-0137-8
%X Erectile dysfunction (ED) is an important complication of diabetes. The aim of our study was to determine whether Ferula elaeochytris (FE) root extract could affect ED in streptozotocin (STZ)-induced diabetic rats. Seventy-five adult male Wistar albino rats were equally divided into five groups; control (C), FE (40£¿mg/kg-d), STZ-induced diabetes (60£¿mg/kg) (DM), diabetes£¿+£¿F. elaeochytris (DM£¿+£¿FE), and ethanol (EtOH). After 8 weeks, in vitro and in vivo parameters (intracavernosal pressure [ICP]), testicle and body weight, serum glucose levels, and histopathology were assessed. In the STZ-induced diabetic group, acetylcholine-induced endothelium-dependent relaxation responses, and electrical field stimulation-induced neurogenic and nitrergic relaxation responses were decreased significantly, while FE administration to diabetic rats reversed the decreased nitrergic and neurogenic responses. In the diabetic group, ICP/MAP (0.1375£¿¡À£¿0.02£¿cm/H2O), spermatogenesis in testicles (53.73£¿¡À£¿0.81), and testicle weights (257.8£¿¡À£¿20.63) were decreased significantly; however, FE administration to diabetic rats restored the decreased values (0.350£¿¡À£¿0.019£¿cm/H2O, 75.07£¿¡À£¿0.35, and 416£¿¡À£¿24.11, respectively). In the DM group, blood glucose levels were increased (411.7£¿¡À£¿18.30) compared to the C group. However, FE administration to diabetic rats reduced glucose levels (230.6£¿¡À£¿25.60£¿mg/dL) compared to the DM group. In conclusion, FE recovered neurogenic and endothelial dysfunction and decreased glucose levels in diabetic rats
%U https://www.nature.com/articles/s41443-019-0137-8