%0 Journal Article
%T Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells
%J -
%D 2019
%R https://doi.org/10.1038/s41592-019-0392-0
%X Multimodal single-cell assays provide high-resolution snapshots of complex cell populations, but are mostly limited to transcriptome plus an additional modality. Here, we describe expanded CRISPR-compatible cellular indexing of transcriptomes and epitopes by sequencing (ECCITE-seq) for the high-throughput characterization of at least five modalities of information from each single cell. We demonstrate application of ECCITE-seq to multimodal CRISPR screens with robust direct single-guide RNA capture and to clonotype-aware multimodal phenotyping of cancer samples
%U https://www.nature.com/articles/s41592-019-0392-0