%0 Journal Article %T Instantaneous isotropic volumetric imaging of fast biological processes %J - %D 2019 %R https://doi.org/10.1038/s41592-019-0393-z %X To capture highly dynamic biological processes at cellular resolution is a recurring challenge in biology. Here we show that combining selective-volume illumination with simultaneous acquisition of orthogonal light fields yields three-dimensional images with high, isotropic spatial resolution and a significant reduction of reconstruction artefacts, thereby overcoming current limitations of light-field microscopy implementations. We demonstrate medaka heart and blood flow imaging at single-cell resolution and free of motion artefacts at volume rates£¿of up to 200£¿Hz %U https://www.nature.com/articles/s41592-019-0393-z