%0 Journal Article %T Strategies for binding multiple guests in metal¨Corganic cages %J - %D 2019 %R https://doi.org/10.1038/s41570-019-0085-3 %X The binding of multiple guests by a single entity can lead to new modes of host¨Cguest interactions and thus new applications in, for example, catalysis and sensing. With the aim of developing modular systems that can promote and adapt to allosteric binding events, this Review explores current strategies used to bind multiple guests in the central and peripheral environments of coordination cages. The structural and functional consequences of multi-guest binding are examined, highlighting the methods by which guest configurations involving more than one copy of the same guest, as well as multiple different guests, may be designed. We thus aim to provide new methodological insights and tools into the design of new capsules for multiple guest-specific binding events, towards the development of guest¨Cguest chemistry within synthetic systems %U https://www.nature.com/articles/s41570-019-0085-3