%0 Journal Article
%T Chiral aminophosphines derived from hydroxyproline and their application in allene¨Cimine [4£¿+£¿2] annulation
%J -
%D 2019
%R https://doi.org/10.1038/s41429-019-0181-0
%X A robust synthetic route from l-hydroxyproline (l-Hyp) to phosphines has established an expandable library of six chiral aminophosphines, which were then applied to the phosphine-catalyzed [4£¿+£¿2] allene¨Cimine annulation. The enantioinduction in the annulations¡ªinduced by a purely steric effect¡ªwere moderate (up to 57% ee). A switch of the reaction site from the ¦Ã- to the ¦Â¡ä-carbon atom of the allenoate was observed during the annulations performed using sterically demanding chiral phosphines
%U https://www.nature.com/articles/s41429-019-0181-0