%0 Journal Article
%T A humanized MDCK cell line for the efficient isolation and propagation of human influenza viruses
%J -
%D 2019
%R https://doi.org/10.1038/s41564-019-0433-6
%X Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much more effectively than conventional MDCK or human virus receptor-overexpressing (AX4) cells. A/H3N2 viruses propagated in hCK cells also maintained higher genetic stability than those propagated in MDCK and AX4 cells
%U https://www.nature.com/articles/s41564-019-0433-6