%0 Journal Article
%T Aberrant activation of latent transforming growth factor-¦Â initiates the onset of temporomandibular joint osteoarthritis
%J -
%D 2018
%R https://doi.org/10.1038/s41413-018-0027-6
%X There is currently no effective medical treatment for temporomandibular joint osteoarthritis (TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to investigate the key role of transforming growth factor-¦Â (TGF-¦Â) signalling in the cartilage and subchondral bone of the TMJ using a temporomandibular joint disorder (TMD) rat model, an ageing mouse model and a Camurati¨CEngelmann disease (CED) mouse model. In the three animal models, the subchondral bone phenotypes in the mandibular condyles were evaluated by ¦ÌCT, and changes in TMJ condyles were examined by TRAP staining and immunohistochemical analysis of Osterix and p-Smad2/3. Condyle degradation was confirmed by Safranin O staining, the Mankin and OARSI scoring systems and type X collagen (Col X), p-Smad2/3a and Osterix immunohistochemical analyses. We found apparent histological phenotypes of TMJ-OA in the TMD, ageing and CED animal models, with abnormal activation of TGF-¦Â signalling in the condylar cartilage and subchondral bone. Moreover, inhibition of TGF-¦Â receptor I attenuated TMJ-OA progression in the TMD models. Therefore, aberrant activation of TGF-¦Â signalling could be a key player in TMJ-OA development
%U https://www.nature.com/articles/s41413-018-0027-6