%0 Journal Article %T Heterozygous rare genetic variants in non-syndromic early-onset obesity %J - %D 2019 %R https://doi.org/10.1038/s41366-019-0357-5 %X Obesity is a very heterogeneous disorder at both the clinical and molecular levels and with high heritability. Several monogenic forms and genes with strong effects have been identified for non-syndromic severe obesity. Novel therapeutic interventions are in development for some genetic forms, emphasizing the importance of determining genetic contributions %U https://www.nature.com/articles/s41366-019-0357-5