%0 Journal Article
%T Understanding molecular mechanisms in cell signaling through natural and artificial sequence variation
%J -
%D 2018
%R https://doi.org/10.1038/s41594-018-0175-9
%X The functionally tolerated sequence space of proteins can now be explored in an unprecedented way, owing to the expansion of genomic databases and the development of high-throughput methods to interrogate protein function. For signaling proteins, several recent studies have shown how the analysis of sequence variation leverages the available protein-structure information to provide new insights into specificity and allosteric regulation. In this Review, we discuss recent work that illustrates how this emerging approach is providing a deeper understanding of signaling proteins
%U https://www.nature.com/articles/s41594-018-0175-9