%0 Journal Article
%T The Parkinson¡¯s phenome¡ªtraits associated with Parkinson¡¯s disease in a broadly phenotyped cohort
%J -
%D 2019
%R https://doi.org/10.1038/s41531-019-0077-5
%X In order to systematically describe the Parkinson¡¯s disease phenome, we performed a series of 832 cross-sectional case-control analyses in a large database. Responses to 832 online survey-based phenotypes including diseases, medications, and environmental exposures were analyzed in 23andMe research participants. For each phenotype, survey respondents were used to construct a cohort of Parkinson¡¯s disease cases and age-matched and sex-matched controls, and an association test was performed using logistic regression. Cohorts included a median of 3899 Parkinson¡¯s disease cases and 49,808 controls, all of European ancestry. Highly correlated phenotypes were removed and the novelty of each significant association was systematically assessed (assigned to one of four categories: known, likely, unclear, or novel). Parkinson¡¯s disease diagnosis was associated with 122 phenotypes. We replicated 27 known associations and found 23 associations with a strong a priori link to a known association. We discovered 42 associations that have not previously been reported. Migraine, obsessive-compulsive disorder, and seasonal allergies were associated with Parkinson¡¯s disease and tend to occur decades before the typical age of diagnosis for Parkinson¡¯s disease. The phenotypes that currently comprise the Parkinson¡¯s disease phenome have mostly been explored in relatively small purpose-built studies. Using a single large dataset, we have successfully reproduced many of these established associations and have extended the Parkinson¡¯s disease phenome by discovering novel associations. Our work paves the way for studies of these associated phenotypes that explore shared molecular mechanisms with Parkinson¡¯s disease, infer causal relationships, and improve our ability to identify individuals at high-risk of Parkinson¡¯s disease
%U https://www.nature.com/articles/s41531-019-0077-5