%0 Journal Article
%T Epigenetic predictive biomarkers for response or outcome to platinum-based chemotherapy in non-small cell lung cancer, current state-of-art
%J -
%D 2018
%R https://doi.org/10.1038/s41397-018-0029-1
%X Platinum-based chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC). However, its efficacy is limited and no molecular biomarkers that predict response are available. In this review, we summarize current knowledge concerning potential epigenetic predictive markers for platinum-based chemotherapy response in NSCLC. A systematic search of PubMed and ClinicalTrials.gov using keywords ˇ°non-small cell lung cancerˇ± combined with ˇ°chemotherapy predictive biomarkersˇ±, ˇ°chemotherapy epigenetics biomarkersˇ±, ˇ°chemotherapy microRNA biomarkersˇ±, ˇ°chemotherapy DNA methylationˇ± and ˇ°chemotherapy miRNA biomarkersˇ± revealed 1740 articles from PubMed and 36 clinical trials. Finally, 22 papers and no trials fulfilled the review criteria. Among miRNA, combination of miR-1290, miR-196b and miR-135a in tumor tissue, and miR-21, miR-25, miR27b, and miR-326 in plasma were predictive for response to platinum-based chemotherapy in advanced NSCLC. RASSF1A methylation measured in tumor or blood was predictive for response to neoadjuvant chemotherapy. These biomarkers remain experimental and none have been tested in a prospective trial
%U https://www.nature.com/articles/s41397-018-0029-1