%0 Journal Article
%T Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy
%J -
%D 2018
%R https://doi.org/10.1038/s41698-018-0065-y
%X Radiotherapy shows excellent local control in liver cancers but carries the risk of radiation-induced liver dysfunction and liver failure. We conducted a study of plasma hepatocyte growth factor (HGF) in a clinical trial of proton radiotherapy in patients with unresectable liver cancers (NCT00976898), and in an observational study for liver cancer patients undergoing surgical treatments. Liver dysfunction within 3 months after radiotherapy¡ªa Childs£¿Turcotte£¿Pugh (CTP) score increase of 1 point or more¡ªoccurred in 9/34 (26%) of patients. Patients with no increase in CTP score had lower pretreatment plasma HGF level (p£¿=£¿0.015). Both the increase in CTP score (p£¿=£¿0.034) and the pretreatment plasma HGF (p£¿=£¿0.017) were associated with OS. Plasma HGF was significantly associated with presence of cirrhosis (p£¿=£¿0.0027) and with Model for End-stage Liver Disease (MELD) score (p£¿<£¿0.0001), but not with OS in surgical liver cancer patients. Pretreatment plasma HGF is a candidate biomarker for patient selection for radiotherapy
%U https://www.nature.com/articles/s41698-018-0065-y