%0 Journal Article
%T Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo
%J -
%D 2019
%R https://doi.org/10.1038/s41387-019-0075-z
%X There is evidence that sirtuin 1 (SIRT1), a key regulator of nutrient metabolism, increases ¦Â-cell secretory function. Excess circulating fat, as seen in obesity, has been shown to decrease ¦Â-cell function, an effect that may involve decreased SIRT1 activity. Consequently, SIRT1 activation may increase ¦Â-cell function in conditions of elevated plasma-free fatty acid levels. Here we attempted to attenuate the lipid-induced decrease in ¦Â-cell function in vivo using pharmacological and genetic models of SIRT1 activation
%U https://www.nature.com/articles/s41387-019-0075-z