%0 Journal Article
%T High orange juice consumption with or in-between three meals a day differently affects energy balance in healthy subjects
%J -
%D 2018
%R https://doi.org/10.1038/s41387-018-0031-3
%X Sugar-containing beverages like orange juice can be a risk factor for obesity and type 2 diabetes although the underlying mechanisms are less clear. We aimed to investigate if intake of orange juice with or in-between meals differently affects energy balance or metabolic risk. Twenty-six healthy adults (24.7£¿¡À£¿3.2 y; BMI 23.2£¿¡À£¿3.2£¿kg/m2) participated in a 4-week cross-over intervention and consumed orange juice (20% of energy requirement) either together with 3 meals/d (WM) or in-between 3 meals/d (BM) at ad libitum energy intake. Basal and postprandial insulin sensitivity (primary outcome), daylong glycaemia, glucose variability and insulin secretion were assessed. Body fat mass was measured by air-displacement plethysmography. After BM-intervention, fat mass increased (+1.0£¿¡À£¿1.8£¿kg; p£¿<£¿0.05) and postprandial insulin sensitivity tended to decrease (¦¤MatsudaISI: £¿0.89£¿¡À£¿2.3; p£¿=£¿0.06). By contrast, after WM-intervention fat mass and gamma-glutamyl transferase (GGT) decreased (£¿0.30£¿¡À£¿0.65£¿kg; £¿2.50£¿¡À£¿3.94; both p£¿<£¿0.05), whereas glucose variability was higher (¦¤MAGE: +0.45£¿¡À£¿0.59, p£¿<£¿0.05). Daylong glycaemia, insulin secretion, changes in basal insulin sensitivity, and triglycerides did not differ between WM- and BM-interventions (all p£¿>£¿0.05). In young healthy adults, a conventional 3-meal structure with orange juice consumed together with meals had a favorable impact on energy balance, whereas juice consumption in-between meals may contribute to a gain in body fat and adverse metabolic effects
%U https://www.nature.com/articles/s41387-018-0031-3