%0 Journal Article
%T Signal-induced PARP1-Erk synergism mediates IEG expression
%J -
%D 2019
%R https://doi.org/10.1038/s41392-019-0042-0
%X A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy
%U https://www.nature.com/articles/s41392-019-0042-0