%0 Journal Article
%T Human Interferon Alpha2a as Anti Hepatitis B and C
%J -
%D 2017
%R https://doi.org/10.15416/ijcp.2017.6.4.298
%X Hepatitis is an inflammation of the liver mainly caused by hepatitis viruses. There are 5 different types of hepatitis based on the infecting virus; A, B, C, D and E. Hepatitis B and C are chronic diseases that potentially develop into hepatocarcinoma and cirrhosis on unappropriate treatments. World Health Organization (WHO) stated that currently 350 million people worldwide are living with chronic hepatitis B and 150 million people are living with Hepatitis C. The mortality rate in the world due to hepatitis is about 1.5 million people per year. The human interferon alpha2a (hIFN¦Á2a) is a therapeutic protein used as therapeutic protein for hepatitis B and C. This review discusses the hepatitis B (HBV) and C (HCV) viruses, mechanisms of hIFN¦Á2a as antivirus through signal transduction pathway and improvement of hIFN¦Á2a properties by protein modification. The application of recombinant hIFN¦Á2a (rhIFN¦Á2a) in the treatment of hepatitis B and C that recommended by European Association for The Study of Liver (EASL) and the viral resistance mechanism are also included. The status of hepatitis B and C and the development of rhIFN¦Á2a is also described as well
%K Antiviral
%K hepatitis
%K human interferon alpha2a
%K protein modification
%K viral resistance
%U http://dx.doi.org/10.15416/ijcp.2017.6.4.298