%0 Journal Article
%T PREPARATION AND CHARACTERIZATION OF CO-CRYSTALS OF DIACEREIN
%A L N Barde
%A N M Mahajan
%A N P Tekade
%A P V Ajmire
%A Raju Rameshrao Thenge
%A V B Patond
%J -
%D 2017
%R http://dx.doi.org/10.14499/indonesianjpharm28iss1pp34
%X Diacerein, anti-inflammatory drug used in the treatment of osteoarthritis. Being a BCS class II drug, it has poor solubility, dissolution rate and other physicochemical properties. Thus the aim of present study was to prepare co-crystals of diacerein to improve solubility, dissolution rate. The diacerein co-crystals were prepared using urea and tartaric acid as conformer by Solvent drop grinding method. The diacerein co-crystals were characterized by scanning electron microscopy (SEM), FT-IR spectroscopy (FT-IR), Differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). The co-crystals were evaluated for solubility, dissolution rate and other physicochemical properties and compared with commercial diacern sample. The co-crystals exhibit the difference in the size and shape of crystals. The FT-IR spectra of diacerein co-crystals showed slightly different in the characteristic peaks compared to commercial diacerein sample. DSC data indicate the decrease in the melting endotherm of co-crystals compare to diacerein. The co-crystals with urea showed increase and intense peak and co-crystals with tartaric acid showed decreased number of peaks compared to commercial diacerein. The co-crystals of diacerein formulated in to the Tablet and evaluated for tablet properties. The tablet formulation showed improved tablet characteristics as well as dissolution rate compared to commercial diacerein
%K Co-crystals
%K Diacerein
%K physicochemical properties
%K FT-IR
%U http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1157