%0 Journal Article
%T THE IN VITRO ANTIOXIDANT PROPERTIES OF 2-ALKOXYPHENYLCARBAMIC ACID DERIVATIVES CONTAINING A 4¡ä-(SUBSTITUTED PHENYL)PIPERAZIN-1¡ä-YL MOIETY DETERMINED BY THE 2,2¡ä-AZINOBIS(3-ETHYLBENZOTHIAZOLINE-6-SULFONIC ACID) DERIVED RADICAL CATION (ABTS£¿+) AND FERRIC RE
%A Ivan Mal¨ªk
%A Jana £¿urillov¨¢
%A Jozef Cs£¿llei
%A Luk¨¢£¿ Stanzel
%J -
%D 2017
%R http://dx.doi.org/10.14499/indonesianjpharm28iss1pp1
%X In an effort to comprehensively characterize an antioxidant profile of 2-alkoxyphenylcarbamic acid-based compounds containing a 4¡ä-(substituted phenyl)piperazin-1¡ä-yl fragment, they were in vitro screened in the 2,2¡ä-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) derived radical cation (ABTS£¿+) and ferric reducing antioxidant power (FRAP) assay using the UV/VIS spectrophotometry. The ABTS£¿+ scavenging (reducing) potential of 1-[3-(2-methoxyphenylcarbamoyl)oxy-2-hydroxypropyl]-4-(4-fluorophenyl)piperazin-1-ium chloride was found to be the most promising and it was comparable to the efficiency of the carvedilol reference drug. Moreover, that 4¡ä-fluoro group-containing compound was regarded as more active than the atenolol standard. When testing the molecules¡ä power to reduce the ferric 2,4,6-tris (2-pyridyl)-s-triazine complex [Fe(III)(TPTZ)2]3+, the most prospective was 1-[3-(2-ethoxyphenylcarbamoyl)oxy-2-hydroxypropyl]-4-(4-fluorophenyl)piperazin-1-ium chloride. On the other hand, its Fe3+ reducing power was lower compared to both standards carvedilol and atenolol. The study discussed structure¨Cantioxidant properties relationships considering electronic, steric and lipophilic features
%K Substituted phenylcarbamates
%K N-arylpiperazines
%K antioxidant properties
%K ABTS£¿+
%K FRAP
%K electronic features
%K lipophilicity
%U http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1156