%0 Journal Article
%T Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System
%A Agung Endro Nugroho
%A Ika Yuni Astuti
%A Marchaban Marchaban
%A Ronny Martien
%J -
%D 2018
%R http://dx.doi.org/10.14499/indonesianjpharm29iss2pp60
%X The recent work focuses on the physical characterization and dissolution study of PGV-0 loaded self-nanoemulsifying drug delivery system (SNEDDS). The PGV-0 SNEDDS was prepared by spontaneous emulsification method using oleic acid, tween 20:labrasol (1:1) and polyethylene glycol 400. The zeta potential of the PGV-0 SNEDDS was -34.4 ¡À 7.66 mv. The nanoemulsion of PGV-0 SNEDDS was thermodynamically stable with forming droplet oil containing PGV-0 in it and spherical. The dissolution result showed that the PGV-0 SNEDDS was able to increase the dissolution significantly (p <0.05) compared with PGV-0 powder of 44.13% in AGF medium and 30.37% in AIF medium. It is concluded that SNEDDS PGV-0 was able to increase the PGV-0 aqueous solubility
%K PGV-0 SNEDDS
%K characterization
%K dissolution
%U http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1285