%0 Journal Article
%T Isolation and Identification of ¦Á-Glucosidase Inhibitor From Aspergillus Terreus F38
%A Rizna Triana Dewi
%A Siti Munasaroh
%A Swasono R Tamat
%J -
%D 2018
%R http://dx.doi.org/10.14499/indonesianjpharm29iss2pp74
%X Controlled postprandial glucose level is an important strategy in preventing DM type 2. Inhibitors of ¦Á-glucosidase have been postulated to be useful agents in managements of DM type 2. This research aims to isolate and identify of ¦Á-glucosidase inhibitor fromAspergillus terreus F38 by liquid fermentation. The mycelium extract of A. terreus F38showed strong activity against ¦Á-glucosidase with IC50 value of 9.65 ¦Ìg/mL. Separation and purification of mycelium ectract yielded compound I (Butyrolactone III). The structure was establish on the basis of spectral analysis, according to the data obtained by NMR and LCMS-MS experiments. Compound I showed potential activity against ¦Á-glucosidase with IC50 value of 13.87 ¦Ìg/mL. Therefore, the metabolites from A. terreus F38 can be used as lead compound to design potent ¦Á-glucosidase inhibitory agents
%K ¦Á-glukosidase inhibition
%K Aspergillus terreus F38
%K butyrolactone III.
%U http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1323