%0 Journal Article
%T HIV associated neurocognitive disorders
%A Li Zhou
%A Nitin K. Saksena
%J -
%D 2013
%R https://doi.org/10.4081/idr.2013.s1.e8
%X Human immunodeficiency virus type 1 is associated with the development of neurocognitive disorders in many infected individuals, including a broad spectrum of motor impairments and cognitive deficits. Despite extensive research, the pathogenesis of HIV-associated neurocognitive disorders (HAND) is still not clear. This review provides a comprehensive view of HAND, including HIV neuroinvasion, HAND diagnosis and different level of disturbances, influence of highly-active antiretroviral therapy to HIV-associated dementia (HAD), possible pathogenesis of HAD, etc. Together, this review will give a thorough and clear understanding of HAND, especially HAD, which will be vital for future research, diagnosis and treatment
%K HIV associated neurocognitive disorders
%K HIV associated dementia
%K blood brain barrier
%K cytokine
%K chemokine
%K macrophage
%K soluble factors
%U https://www.pagepress.org/journals/index.php/idr/article/view/idr.2013.s1.e8