%0 Journal Article
%T Hepatic and Systemic Effect of Non-Alcoholic Fatty Liver Disease Severity in Obese and Non-Obese Indian Patients
%A Acharya
%A Baibaswata
%A Das
%A Dr
%A Krishnendu
%A Kumar
%A Mondol
%A Nadda
%A Nayak
%A Neelanjana
%A Neeti
%A Nongthombam
%A Perumal
%A Prasenjit
%A Roy
%A Shalimar
%A Subrat
%A Suraj
%A Vanamail
%A Virendra
%J -
%D 2018
%R 10.18314/igh.v1i1.1405
%X Background: Non-alcoholic fatty liver disease (NAFLD) is now predominant globally due to increased sedentary lifestyle and obesity. Recently, high prevalence of NAFLD also has been documented in non-obese individuals with increased risk of cirrhosis and hepatocellular carcinoma. The systemic and hepatic manifestations of NAFLD severity in obese and non-obese Indian patients are not clear. Methods: The clinically diagnosed NAFLD patients (n=54, non-obese and obese) were assessed for liver injury and hepatic fat content by histopathology, Fibroscan and MRS. Liver biopsy and hepatic venous sampling were performed by trans-jugular approach and mRNA expression was assessed by real-time PCR. Result: High liver fat content (LFC, 20. 4 ¡À 10. 4%, 16 ¡À 11. 5% and 9. 34 ¡À 15. 4%) and increased abdominal obesity (WHR, 1. 03 ¡À 0. 06, 0. 97 ¡À 0. 05 and 0. 93 ¡À 0. 06) was observed in both obese and non-obese NAFLD patients as compare to disease control. Histopathological examination of liver indicated increased fibrosis (grade ¡Ý 1) in both obese (76%) and non-obese (64%) group. Significant increased levels of LBP, MDA and adipokines levels (p < 0. 001) were observed in hepatic and systemic circulation of obese and non-obese groups than healthy and diseased controls. A positive correlation of biomarkers for liver injury was found between hepatic and systemic circulation. Hepatic gene expression of adipokines and cytokines also corroborated this trend among groups. Conclusion: The extent of liver injury is quite high in both non-obese and obese NAFLD patients. The drivers of injury in these patients are due to hepatic fat and SIBO induced endotoxin mediated up-regulation of proinflammatory adipocytokines and oxidant stress in liver
%U https://www.gratisoa.org/journals/index.php/IGH/article/view/1405