%0 Journal Article
%T Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy
%A Akgul Arici
%A Aysun Ekinci
%A Demet Arslan
%A Eda Bozdemir
%A Esref Akil
%A Hasan Huseyin Ozdemir
%J -
%D 2017
%X Despite recent advances in antibiotic therapy, sepsis remains a major clinical challenge in intensive care units. Here we examined the anti-inflammatory and antioxidant effects of Ecballium elaterium (EE) on brain, and explored its therapeutic potential in an animal model of sepsis-associated encephalopathy (SAE) [induced by cecal ligation and puncture (CLP)].
%K control
%K sepsis
%K and treatment. Rats were subjected to CLP except for the control group
%K which underwent laparatomy only. The treatment group received 2.5 mg/kg EE while the sepsis group was administered by saline. Twenty-four hours after laparotomy
%K animals were sacrificied and the brains were removed. Brain homogenates were prepared to assess interleukin 1beta (IL-1¦Â)
%K interleukin 6 (IL-6)
%K tumor necrosis factor alpha (TNF-¦Á)
%K total antioxidant capacity (TAC)
%K and total oxidant status (TOS). Brain tissue sections were stained by hematoxylin and eosin (H&E) to semi-quantitatively examine the histopathologic changes such as neuron degeneration
%K pericellular/perivascular edema and inflammatory cell infiltration in the cerebral cortex.
%U https://www.ajol.info/index.php/ljm/article/view/161501