%0 Journal Article
%T Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
%A A.A. Akinlolu
%A G.O. Adunmo
%A G.O. Omotoso
%A I.T. Gbadamosi
%A M.O. Ameen
%A M.O. Lawal
%A R.E. Kadir
%A R.M. Kolo
%A S.F. Lewu
%J -
%D 2018
%X Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.
%K demyelination
%K cuprizone
%K cerebellar damage
%K Moringa oleifera
%K oxidative enzymes
%U https://www.ajol.info/index.php/rejhs/article/view/171305