%0 Journal Article
%T A 3D polyhedral metal¨Corganic framework as drug carrier for controllable release
%A E. H. Zhou
%A H. D. Zeng
%A H. R. Zhong
%A J. C. Jin
%A J. Q. Liu
%A J. W. Xu
%A J. Wu
%A R. Wang
%A S. W. Qiu
%J -
%D 2017
%X A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]£¿12H2O£¿7DMA} (1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.
%U https://www.ajol.info/index.php/bcse/article/view/165350