%0 Journal Article
%T Morphologic and immunophenotypic features of a case of acute monoblastic leukemia with unusual positivity for Glycophorin-A
%A Antonio Azzarš€
%A Cristiana Domenichini
%A Francesco Caracciolo
%A Giovanni Carulli
%A Maria Immacolata Ferreri
%A Mario Petrini
%A Martina Rousseau
%A Paola Sammuri
%A Virginia Ottaviano
%J -
%D 2016
%R https://doi.org/10.4081/hr.2018.7823
%X Acute monoblastic leukemia (AMoL) is characterized by cells with highly undifferentiated morphology. Cytochemistry with non-specific esterases is negative in up to 20% of cases. Immunophenotyping by flow cytometry has an essential role in diagnosing such a subtype of leukemia and a multiparametric approach with a wide monoclonal antibody panel is necessary. We describe a case of AMoL with morphology resembling either plasma blasts or very immature erythroblasts. Diagnosis was made by alpha-naphtyl-acetate esterase staining and with immunophenotyping, which was made with a wide monoclonal antibody panel. Blasts were positive for monocytic markers. Most of leukemic cells, however, were positive for Glycophorin-A. The presence of Glycophorin-A, which is considered as a specific marker of the erythroid lineage, has never been reported previously in cases of AMoL. This peculiar immunophenotype might be interpreted as deriving from a common myelo-erythroid precursor undergone leukemic transformation.
%U https://www.pagepress.org/journals/index.php/hr/article/view/7823