%0 Journal Article
%T Assessment and comparison of the levels of N-nitrosonornicotine and 4-(n-methyl-n ¨Cnitrosamino) -1-(3-pyridyl)-1-butanone in the saliva of tobacco chewers and non- chewers -a hospital based study
%A Dr Anjana Bagewadi
%A Dr Harpreet Kaur Gandhoke
%A Dr Vasanti Lagali Jirge
%J -
%D 2018
%R 10.14419/ijdr.v6i2.11943
%X Background: Studies estimating the Tobacco- specific nitrosamines, (TSNA¡¯s) which are the strongest carcinogens in the saliva of tobacco users and tobacco quitters, are limited. Objectives: To assess and compare the levels of N- nitrosamines (NNN, NNK) in the saliva of tobacco chewers and non -chewers including those who have quit the habit of tobacco use. Methods: The study included 120 patients who were divided into three groups of 40 each: Group I- Smokeless tobacco chewers Group II- Tobacco chewers who have completely stopped the habit at least 2 weeks prior to sample collection and Group III- non-chewers. The salivary levels of two tobacco specific nitrosamines; NNN & NNK levels were estimated in the three study groups. Statistical analysis was done by Kruskal¨C Wallis, one-way analysis of variance (ANOVA) test, Mann-Whitney U test. (p-value < 0.05 was considered to be statistically significant) Results: In Group I, the mean level of NNN was 651.84 ¡À 359.78 and mean level of NNK was 168.32 ¡À 131.83. In Group II, the mean level of NNN was 119.52 ¡À 95.05 and mean level of NNK was 42.78 ¡À 43.19. In Group III, the mean level of NNN was 3.44 ¡À6.55 and mean level of NNK was 1.98 ¡À 3.68. There was a statistical difference in the 3 groups with respect to mean levels of NNN and NNK. Conclusion: The study indicated that salivary tobacco-specific nitrosamines are elevated in tobacco chewers. Saliva can be used to detect TSNA¡¯s and screen for TSNA¡¯s during each patient¡¯s de-addiction process.
%U https://www.sciencepubco.com/index.php/IJDR/article/view/11943