%0 Journal Article
%T Possible Mimics of Duffy Binding Protein-II for Plasmodium vivax Binding Endothelial Cells or Binding Plasmodium falciparum by Mimicking Epitope on Erythrocyte Binding Antigen-175 A
%J -
%D 2018
%X Two molecules from the same source, ¦ª casein, are suggested as treatments to prevent infection by Plasmodium vivax, malaria virus, through the prevention of Duffy Binding Protein II (DBPII) monomers 1 and 2 from binding. By preventing DBPII monomer 1 and 2 binding there would be half the Duffy Antigen Receptor for Chemokines (DARC) binding to the DBPII trimer. This may prevent infection by this virus. Here the essential, structural, characterization of two potential binding mimics of the DBPII monomer 2 to prevent its binding to DBPII monomer 1, are provided. ¦ª casein is treated with NaBH4 in 1 N NH4OH (pH 11.4) to produce the two molecules; N-acetamido deoxy neuraminyl (¦Á 2->3¡¯) N-acetamido deoxy neuraminyl (¦Á 2->6¡¯) galactosyl 4¡¯ (di-hydrido) sulfo (¦Â 1->3) N-acetamido deoxy galactosaminyl 6 (di-hydrido) sulfo di-(hydrido) di-phospho serinyl (di-hydrido) sulfo tyrosine dipeptide and N-acetamido deoxy neuraminyl (¦Á 2->3¡¯) N-acetamido deoxy neuraminyl (¦Á 2->6¡¯) 4¡¯ (di-hydrido) sulfo galactosyl (¦Â 1-> 3) 6 (d-hydrido) sulfo 1,5 anhydro N-acetamido deoxy galactosaminitol. Only the first of the two molecules presents a (di-hydrido) sulfo tyrosine, yet both have two (di-hydrido) sulfo groups. Still the dipeptide may mimic another sulfo tyrosine on the DBPII monomer 2, thought to be away from T266 (threonine 266) a significant distance, possibly Y363 of DBPII monomer 2. These molecules may also mimic the appropriate epitope on Erythrocyte Binding Antigen (EBA)-175 of Plasmodium falciparum to prevent infection by this virus
%K Carbohydrate Mimics
%K Malaria Infection
%K ¦ª Casein
%K Hydride Chemistry
%K Mass Spectrometry
%K HPAEC-PAD
%U http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=540&doi=10.11648/j.wjfst.20180202.14