%0 Journal Article
%T Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection?
%A Agnieszka Malecka
%A Gunhild Tr£¿en
%A Jan Delabie
%A Klaus Beiske
%A Panagiota Mantaka
%A Per Helsing
%A Petter Gjersvik
%J -
%@ 1651-2057
%D 2017
%R 10.2340/00015555-2722
%X Folliculotropic mycosis fungoides (FMF), a variant of mycosis fungoides (MF) with distinct clinical features, is characterized by infiltration of malignant T cells in hair follicles. This raises the hypothesis that antigens in the hair follicle may contribute to the pathogenesis of FMF. T-cell receptor ¦Â gene (TRB) sequences as well as dendritic cell subsets in patients with FMF (n£¿=£¿21) and control patients with MF (n£¿=£¿20) were studied to explore this hypothesis. A recurrent usage of the TRB junctional genes TRBJ2-1 and TRBJ2-7 was found in patients with FMF compared with those with MF. These genes contribute to an amino acid motif in the complementarity-determining region 3 (CDR3) of the T-cell receptor. This motif was previously found in T cells stimulated by lipids bound to CD1 on antigen-presenting cells. Additional immunohistochemical analysis revealed abundant CD1c- and CD1a- expressing dendritic cells in FMF. The combined findings support a role for lipid-antigen stimulation in FMF.
%U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2722