%0 Journal Article
%T Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus
%A Elisabet Nylander
%A Karin Danielsson
%A Karin Nylander
%A Majid Ebrahimi
%A Ylva Britt Wahlin
%J -
%@ 1651-2057
%D 2017
%R 10.2340/00015555-2533
%X Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.
%U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2533