%0 Journal Article %T Dermal CD271+ Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process %A Akiko Yagami %A Hirohiko Akamatsu %A Kayoko Matsunaga %A Kazumitsu Sugiura %A Satoru Nakata %A Seiji Hasegawa %A Yohei Iwata %A Yuichi Hasebe %J - %@ 1651-2057 %D 2017 %R 10.2340/00015555-2624 %X Stem cells have recently been shown to play important roles in wound healing. The aim of this study was to investigate the role of dermal CD271+ cells in wound healing. Full-thickness wounds were produced on the backs of 5-year-old and 24-week-old mice, and time-course of wound closure, CD271+ cell counts, and gene expression levels were compared. Delayed wound healing was observed in 24-week-old mice. The peak of CD271+ cell increase was delayed in 24-week-old mice, and gene expression levels of growth factors in wounded tissue were significantly increased in 5-year-old mice. Dermal CD271+ cells purified by fluorescence-activated cell sorting (FACS) expressed higher growth factors than CD271¨C cells, suggesting that CD271+ cells play important roles by producing growth factors. This study also investigated dermal CD271+ cells in patients with chronic skin ulcers. Dermal CD271+ cells in patients were significantly reduced compared with in healthy controls. Thus, dermal CD271+ cells are closely associated with wound healing. %U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2624