%0 Journal Article
%T Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor
%A Anna M. Tallman
%A Gil Yosipovitch
%A Jonathan I. Silverberg
%A Lee T. Zane
%A Linda F. Stein Gold
%A Mark G. Lebwohl
%J -
%@ 1651-2057
%D 2018
%R 10.2340/00015555-2893
%X Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ¡Ý£¿1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p£¿<£¿0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p£¿=£¿0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.
%U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2893