%0 Journal Article
%T Efficacy of Botulinum Toxin B Injection for Raynaud¡¯s Phenomenon and Digital Ulcers in Patients with Systemic Sclerosis
%A Akihito Uehara
%A Akiko Sekiguchi
%A Chisako Fujiwara
%A Kazuya Yamada
%A Osamu Ishikawa
%A Sayaka Toki
%A Sei-ichiro Motegi
%A Tetsuya Nakamura
%A Yuki Date
%J -
%@ 1651-2057
%D 2017
%R 10.2340/00015555-2665
%X The efficacy and safety of botulinum toxin B (BTX-B) for treatment of Raynaud¡¯s phenomenon and digital ulcers in patients with systemic sclerosis was assessed. A total of 45 patients with systemic sclerosis who had Raynaud¡¯s phenomenon were blinded and divided randomly into 4 groups: a no-treatment control group, and 3 treatment groups, using 250, 1,000 or 2,000 international units (U) of BTX-B injections in the hand with more severe symptoms. Four weeks after injection, pain/numbness visual analogue scale scores and Raynaud¡¯s score in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group and the group treated with 250 U BTX-B. These beneficial effects were sustained until 16 weeks after the single injection. At 4 weeks after injection skin temperature recovery in the group treated with 2,000 U BTX-B was significantly improved. The numbers of digital ulcers in the groups treated with 1,000 and 2,000 U BTX-B were significantly lower than in the control group. In conclusion, 1,000 and 2,000 U BTX-B injections significantly suppressed the activity of Raynaud¡¯s phenomenon and digital ulcers in patients with SSc without serious adverse events.
%U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2665