%0 Journal Article
%T Interleukin-31 Polymorphisms and Serum IL-31 Level in Patients with Mastocytosis: Correlation with Clinical Presentation and Pruritus
%A Agata Zawadzka
%A Aleksandra G¨®rska
%A Bogus£¿aw Nedoszytko
%A Hanna £¿ugowska-Umer
%A Jolanta Gle¨½
%A Krzysztof R£¿ba£¿a
%A Magdalena Lange
%A Marek Niedoszytko
%A Ma£¿gorzata Soko£¿owska-Wojdy£¿o
%A Monika Sikorska
%A Monika Zab£¿otna
%A Roman Nowicki
%J -
%@ 1651-2057
%D 2017
%R 10.2340/00015555-2474
%X Data on interleukin-31 (IL-31) involvement in the patho-genesis of mastocytosis, and its impact on pruritus development in the disease, are limited. The aim of this study was to analyse distinct IL-31 gene polymorphisms in 127 patients (age 0.5¨C76 years) with mastocytosis and their correlation with clinical presentation, pruritus and serum IL-31 levels. In patients with mastocytosis, the frequency of IL-31 IVS2+12AA genotype and IVS2+12A allele was higher than in control subjects and they were linked to an increased risk of development of mastocytosis. In adult patients, but not in children, -2057AA genotype was also associated with an increased risk of occurrence of mastocytosis. Pruritus affected 83.3% of 78 adult patients with mastocytosis, and a positive correlation between serum IL-31 levels and pruritus was found in these patients. In conclusion, distinct polymorphic variants of the IL-31 gene may be involved in the patho-genesis of mastocytosis, and IL-31 may be involved in the induction of pruritus in patients with mastocytosis.
%U http://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2474