%0 Journal Article
%T Sensitivity and specificity of CRP as a parameter of atherosclerosis in patients with type II diabetes mellitus
%A Doaa Mizar
%A Hoda Hussein
%A Maher Elamir
%A Mohammad Mashaheet
%J -
%D 2014
%R 10.14419/ijbas.v3i3.3022
%X Background: Type 2 diabetes mellitus (T2DM) is an inflammatory atherosclerotic condition with high prevalence of cardiovascular disease. Elevated C-reactive protein (CRP) predicts cardiovascular events in T2DM patients. Objectives: Our work aimed to assess sensitivity and specificity of CRP in diagnosis and follow up of carotid atherosclerosis in T2DM patients (detected by measuring carotid intima-media thickness CIMT). Design and setting: It is observational cross sectional study on T2DM patients from outpatient clinic of fayoum university hospital. Subjects and methods: Hundred patients with T2DM were included; Group I: statin un-treated, Group II: statin treated, and fifty healthy control persons. Laboratory measurement of total cholesterol, LDL, HDL, and serum CRP levels and carotid duplex scanning were done. Results: The patients had higher levels of CRP and CIMT than control. There was strong correlation between CIMT and CRP level among group I and II. LDL in diagnosis of atherosclerosis disease illustrated sensitivity (80%) and specificity (4%), while HDL sensitivity (96%) and specificity (36%). CRP showed higher sensitivity (98%) and higher specificity (72%). Conclusion: CRP level was an important parameter of atherosclerosis with good sensitivity and specificity regardless the level of LDL and HDL.  Keywords: Carotid Intima Media Thickness, C Reactive Protein, Type 2 Diabetes Mellitus.
%U https://www.sciencepubco.com/index.php/ijbas/article/view/3022