%0 Journal Article
%T Ethanolic leaf extract of Irvingia gabonensis (o¡¯Rorke) Baill protects against nephrotoxocity and hepatotoxicity in cadmium-induced wistar albino rats
%A Efosa Ewere
%A Samson Oyebadejo
%A Victor Peter
%J -
%D 2016
%R 10.14419/ijpt.v4i2.6186
%X Cadmium is a well-known environmental pollutant that has been proven to be nephrotoxic and hepatotoxic in the body. In this study, the effect of ethanolic leaf extract of Irvingia gabonensis (O¡¯Rorke) Baill (IG) against cadmium-induced nephrotoxicity and hepatotoxicity in Wistar albino rats was investigated. 30 female wistar rats of weights between 98-153g were grouped into 6 groups of 5 animals each. Group 1 served as the control and was placed on rat feed and water. Groups 2, 3, and 4 were administered 10mg/Kg body weight (mg/kgbw) of cadmium chloride (CdCl2) only,10mg/Kgbw CdCl2 and 200mg/kgbw extract, 10mg/Kgbw CdCl2 and 400mg/kgbw extract, respectively. Groups 5 and 6 were given 200mg/kgbw and 400mg/kgbw of IG extract respectively and the treatments lasted for 28 days. Results obtained revealed significant (p<0.05) increases in the serum levels of all renal and liver function biomarkers in group 2 (CdCl2 only) as compared with the control. There were however significant (p<0.05) decreases in the serum levels of the assayed parameters when groups 3 and 4 were respectively compared with group 2. It can therefore be concluded that ethanolic leaf extract of Irvingia gabonensis (O¡¯Rorke) Baill enhances the integrity of the kidneys and liver of cadmium-induced wistar albino rats.
%U https://www.sciencepubco.com/index.php/IJPT/article/view/6186