%0 Journal Article
%T Clinical Evaluation after Introduction of Stem Cell Supernatant Biocell Shot 65 by Electroporation
%A Ryusuke Suzuki
%A Harue Suzuki
%A Maki Yokogawa
%A Junichi Motohashi
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 58-70
%@ 2161-4512
%D 2021
%I Scientific Research Publishing
%R 10.4236/jcdsa.2021.111006
%X <strong><span style=\"font-family:Verdana;\">Objectives</span></strong><span style=\"font-family:Verdana;\">:</span><span \"=\"\"><span style=\"font-family:Verdana;\"> The
objective of this study is clinical evaluation after introduction of stem cell
supernatant Biocell Shot 65 by electroporation. </span><b><span style=\"font-family:Verdana;\">Background:</span></b></span><span \"=\"\"><span style=\"font-family:Verdana;\"> There is a clinical report of psoriasis treatment by umbilical cord
blood-derived stem cells, in which there was a beneficial result. These
clinical results are the result of cord blood-derived cell growth factors. The
umbilical cord blood-derived stem cell culture supernatant contains a high
amount of TGF-</span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">, PDGA, etc., and
promotes wound healing. In addition, we suppose </span><span style=\"font-family:Verdana;\">that the supernatant has the esthetic effect of improving skin
condition, thus,</span><span style=\"font-family:Verdana;\"> we planned to make a clinical evaluation. However, it
is difficult to set judgement criteria, and human judgement tends to be
subjective. Therefore, in this study, as a new clinical evaluator, we used an
AI skin diagnostic device with learning function. </span><b><span style=\"font-family:Verdana;\">Methods:</span></b><span style=\"font-family:Verdana;\"> Stem cell
culture supernatant Biocell Shot 65 was used as an introduction solution. After
it was applied to the full faces of four patients, electroporation with BeBe
pinocchio DM-5 SUPER DX Plus promoted infiltration deep in the keratinized
layer. The patients were all </span><span style=\"font-family:Verdana;\">healthy women
in their forties. This procedure was performed every two weeks</span><span style=\"font-family:Verdana;\"> for three
months. Wrinkles, fine lines around eyes, stains, pores, and 4V, </span><span style=\"font-family:Verdana;\">which is considered as one diagnostic criteria,
were evaluated at baseline</span><span style=\"font-family:Verdana;\"> and after each procedure with the skin
diagnostic device HiMirror-Professional. In this study, macroscopic findings
were not examined. </span><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\"> In all four patients, 4V did not change
remarkably. Patient 1 showed improvement after the procedure in wrinkles, fine
lines around eyes, stains, and pores. Patient 2 revealed improvement only in
fine lines around eyes, but did not show improvement in other
%K Clinical Evaluation
%K Stem Cell
%K Skin Treatment
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=108071