%0 Journal Article
%T New Convenient Synthesis of 8-C-Methylated Homoisoflavones and Analysis of Their Structure by NMR and Tandem Mass Spectrometry
%A Santosh Kumar Yadav
%J International Journal of Organic Chemistry
%P 46-54
%@ 2161-4695
%D 2021
%I Scientific Research Publishing
%R 10.4236/ijoc.2021.111005
%X Homoisoflavonoids are in the subclass of the larger family of flavonoids having one more alkyl carbon than flavonoids. Among them, 8-C-Methylated homoisoflavones have not been extensively studied for synthesis and biological evaluation. AuthorĄ¯s current objective is to synthesize 8-C-Methylated homoisoflavones by the reaction of 3-C-methylated dihydrochalcones with N,NĄ¯-dimethyl (chloromethylene) ammonium chloride generated<em> in situ</em> from DMF and PCl<sub>5</sub> for one carbon extension at about room temperature. The 3-C-methylated dihydrochalcones were synthesized by the reduction of 3-C-methylated chalcones, which were prepared from 3-C-methylated acetophenones and aromatic aldehydes in the presence of base. All the synthesized novel homoisoflavonesĄ¯s structures were characterized by NMR and Tandem Mass Spectrometry.
%K 8-C-Methylated Homoisoflavones
%K 3-C-Methylated Dihydrochalcones
%K 3-C-Methylated Chalcones
%K 3-C-Methylated Acetophenones
%K Dimethylformamide
%K BF&lt
%K sub&gt
%K 3&lt
%K /sub&gt
%K &amp
%K middot
%K Et&lt
%K sub&gt
%K 2&lt
%K /sub&gt
%K O
%K PCl&lt
%K sub&gt
%K 5&lt
%K /sub&gt
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=108051