%0 Journal Article
%T Antioxidant and Immunopotentiating Effects of <i>Cordyceps </i> Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models
%A Hoi Yan Leung
%A Choly Tat Ming Yan
%A Kam Ming Ko
%J Chinese Medicine
%P 1-9
%@ 2151-1926
%D 2021
%I Scientific Research Publishing
%R 10.4236/cm.2021.121001
%X <i><span style=\"font-family:Verdana;\">Cordyceps</span></i><span style=\"font-family:Verdana;\"> mycelium extract (Cs-4), Chicken Essence (CE), and their combination were
investigated for antioxidant and immunomodulatory activities in mouse models.
Long-term treatment with Cs-4 or CE at equivalent human doses improved
antioxidant status in various tissues, as evidenced by the enhancement of
mitochondrial glutathione redox status in the brain, liver, heart, and kidney
of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as
indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced
proliferation of mouse splenocytes <i></i></span><i><i><span style=\"font-family:Verdana;\">ex vivo</span></i><span style=\"font-family:Verdana;\"></span></i>. While
doubling of the equivalent human doses of Cs-4 and CE did not further enhance
their antioxidant or immunopotentiating effects, the combined treatment with
Cs-4 and CE at their respective equivalent human doses produced an additive
effect, with the extents of stimulation being larger than those produced by
Cs-4 or CE alone. The results have demonstrated for the first time that the
combined use of Cs-4 and CE can produce an additive effect on both
antioxidation and immunopotentiation that cannot otherwise be achieved by
increasing the equivalent human doses of Cs-4 or CE alone.
%K &lt
%K i&gt
%K Cordyceps&lt
%K /i&gt
%K Chicken Essence
%K Glutathione Redox Status
%K Immunopotentiation
%K Additive Effect
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=107842