%0 Journal Article
%T 3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines
%A Ali Bouattour
%A Mehdi Fakhfakh
%A Souhir Abid El-Gharbi
%A Majdi Abid
%A Ludovic Paquin
%A R¨¦my Le Guevel
%A Thierry Charlier
%A Houcine Ammar
%A Jean-Pierre Bazureau
%J International Journal of Organic Chemistry
%P 24-34
%@ 2161-4695
%D 2021
%I Scientific Research Publishing
%R 10.4236/ijoc.2021.111003
%X The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by <sup>1</sup>H, <sup>13</sup>C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC<sub>50</sub> 15 ¦ÌM).
%K 2-Iminocoumarin
%K Tetrazole
%K Fluorescence
%K Tumor Cell Lines
%K HCT 116
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=107622