%0 Journal Article
%T 以酒精液态饲料评估副干酪乳杆菌Lactobacillus paracasei GKS68之护肝保健功效<br> Evaluation of Lactobacillus paracasei GKS68 on Hepatoprotection with Alcohol Liquid Diet
%A 陈婉屏
%A 蔡侑珊
%A 吴文歆
%A 陈炎炼
%A 陈劲初
%J Hans Journal of Food and Nutrition Science
%P 24-32
%@ 2166-6121
%D 2021
%I Hans Publishing
%R 10.12677/HJFNS.2021.101004
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">过量饮酒易导致代谢过程产生过多自由基，造成氧化压力，影响脂质代谢造成脂肪累积于肝脏，长期会有慢性发炎、肝纤维化与肝癌等病变的风险。近年研究显示益生菌对人体健康扮演重要的角色。本研究以酒精液态饲料评估副干酪乳杆菌Lactobacillus paracasei</span><span style=\"font-size:14px;\"> GKS68之护肝保健功效。连续6周口服GKS68搭配酒精性饲料的C57BL/6雄性鼠动物模式中，小鼠之体重变化及摄取量与负对照组无显着差异；6周后牺牲进行血液生化分析，AST、ALT、TG、TC与负对照组均有显着下降。另外，肝脏相对重量、高剂量组之肝脏中TG、TC与负对照组亦有显着差异；肝脏酵素GSH含量、SOD活性在高剂量组与负对照组相比具有显着提升，显示GKS68可改善酒精引起的肝细胞损伤、有效降低酒精所造成的脂肪堆积，达到肝脏保健之功效。</span><span style=\"font-size:14px;\"><br />
Excessive drinking could increase
free radicals in the metabolic process, causing oxidative stress and accumulation
of abnormal metabolites in the liver which higher the risk of developing
chronic disease such as inflammation, liver fibrosis, and liver cancer. Recent
studies have shown that probiotics are playing an important role as beneficial
supplements to human health. In this study, we evaluated the effect of
probiotics </span><span style=\"font-size:14px;\">Lactobacillus paracasei </span><span style=\"font-size:14px;\">GKS68
(GKS68) on liver protection with alcohol-diet mouse model. Twenty C57BL/6 male
mice were divided into four groups: normal diet, alcohol-diet, alcohol-diet
with low-dosage of GKS68, and alcohol-diet with high-dosage of GKS68. After six
weeks of treatment, there were no significant differences in body weight and
food intake among the alcohol-diet group. However, the GKS68 group showed a
significant decrease in serum ALT, AST, TG, TC and the relative liver weight
when compared to the negative control. In addition, the levels of liver TG and
TC were significantly decreased in the high-dosage of GKS68 with a comparison
of alcohol-diet. A dose-dependent effect was also observed in the concentration
of GSH and the SOD activity with GKS68. These results suggested that the
probiotics GKS68 could reduce the liver damage caused by alcohol drinking and
was a potential candidate as functional supplementary on hepatoprotection.</span> 
</div>
%K 副干酪乳杆菌Lactobacillus paracasei GKS68，肝脏保健，酒精性肝病(ALD)<br> Lactobacillus para-casei GKS68
%K Hepatoprotective Effect
%K Alcoholic Liver Disease (ALD)
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=40509