%0 Journal Article
%T YAP/TAZ蛋白调控病毒侵染与免疫的研究进展<br>Research Progress of YAP/TAZ Protein Regulating Virus Infection and Immunity
%A 邹丰
%A 苟洪伟
%A 黄金华
%A 李晨辉
%A 赵铁军
%J Hans Journal of Biomedicine
%P 8-13
%@ 2161-8984
%D 2021
%I Hans Publishing
%R 10.12677/HJBM.2021.111002
%X YAP/TAZ介导的Hippo信号通路在生命进程中扮演重要角色，它主要调控器官大小，胚胎发育，细胞增殖以及肿瘤发生等。最新研究发现Hippo信号通路关键蛋白YAP/TAZ在调控人类病毒侵染及免疫反应中发挥非常重要的作用。文章总结了YAP/TAZ蛋白的病理学特征，重点介绍YAP/TAZ蛋白在调控人类病毒侵染、复制、诱发疾病以及免疫调控中的功能及其机理，以期为病毒致病机制研究及治疗手段开发提供新的见解和思路。<br />
Accumulating evidence showed that YAP/TAZ mediated Hippo pathway plays a critical role in bio-logical processes, including the control of organ size, embryonic development, cell proliferation, and cancer development. The Hippo signaling pathway key protein YAP/TAZ has been found to play a very important role in human virus infection and immunity. This paper summarizes the pathologic characteristics of YAP/TAZ protein, and focuses on the functions and mechanisms of YAP/TAZ pro-tein in the regulation of human virus infection, replication, disease induction and immune regula-tion. It might give new insights into the research of viral disease and its therapy.
%K YAP/TAZ蛋白，Hippo信号通路，病毒侵染，免疫，发病机理<br>YAP/TAZ
%K Hippo Signaling Pathway
%K Virus Infection
%K Immunity
%K Pathogenesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=39866