%0 Journal Article
%T BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin
%A Am
%A Rahul Pal
%A Satish Kumar Gupta
%A Sonam Verma
%A eep Kaur Kang
%J Cell Adhesion & Migration
%D 2020
%R https://doi.org/10.1080/19336918.2019.1710024
%X ABSTRACT The mechanism by which interferon-gamma (IFN-¦Ã) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-¦Ã led to a decrease in their invasion concomitant with an increased expression of BST2. Silencing of BST2 by siRNA showed a significant increase in their invasion and spreading after treatment with IFN-¦Ã as well as downregulated expression of E-cadherin. Further, STAT1 silencing inhibited the IFN-¦Ã-dependent increase in the expression of BST2 and E-cadherin. Treatment of HTR-8/SVneo cells with IFN-¦Ã led to the activation of AKT, and its inhibition with PI3K inhibitor abrogated IFN-¦Ã-mediated decrease in invasion/spreading and downregulated BST2 and E-cadherin expression. Collectively, IFN-¦Ã decreases the invasion of HTR-8/SVneo cells by STAT1 and AKT activation via increased expression of BST2 and E-cadherin
%U https://www.tandfonline.com/doi/full/10.1080/19336918.2019.1710024