%0 Journal Article
%T Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors
%A Luyu Liu
%A Tibor Rohacs
%J Channels
%D 2020
%R https://doi.org/10.1080/19336950.2020.1734266
%X ABSTRACT The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. This review discusses recent findings on the role of PI(4,5)P2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8
%U https://www.tandfonline.com/doi/full/10.1080/19336950.2020.1734266