%0 Journal Article
%T Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway
%A Aurelia Walczak-Drzewiecka
%A Jaros£¿aw Dastych
%A Joanna Pastwi¨½ska
%A Magdalena £¿ukasiak
%A Marcin Ratajewski
%J Cell Adhesion & Migration
%D 2020
%R https://doi.org/10.1080/19336918.2020.1764690
%X ABSTRACT A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors. We investigated the effect of hypoxia on integrin-mediated mast cell adhesion to fibronectin. We found that it was mediated by the ¦Á5/¦Â1 receptor and that hypoxia significantly upregulated this process. Hypoxia-mediated increases in mast cell adhesion occurred without increased surface expression of integrins, suggesting regulation by inside-out integrin signaling. Hypoxia also mediated an increase in phosphorylation of Akt, and PI3¡¯kinase inhibitors abolished hypoxia-mediated mast cell adhesion. Hypoxia upregulates the function of integrin receptors by PI3¡¯ kinase-dependent signaling. This process might be important for the location of mast cells at inflammatory site
%U https://www.tandfonline.com/doi/full/10.1080/19336918.2020.1764690