%0 Journal Article
%T 阿托品在输尿管镜治疗输尿管下段结石中的应用效果
%A 张刚　于芹超
%J -
%D 2019
%R 10.13362/j.jpmed.201906021
%X 摘要 目的　探讨阿托品注射液在输尿管镜治疗输尿管下段结石中的应用效果。 方法　选取2016年3月—2017年12月于我院拟行输尿管镜碎石术的输尿管下段结石患者106例，采用随机分组分为试验组(53例)与对照组(53例)。试验组手术开始前20 min肌肉注射阿托品0.02 mg/kg；对照组术前不注射阿托品。比较两组进镜成功率和术后并发症等的发生率。 结果　试验组均未出现药物不良反应。两组患者手术过程中输尿管镜进镜成功率差异有显著性（χ2=4.417,P＜0.05）。两组患者术后输尿管穿孔、输尿管黏膜损伤、输尿管抱镜发生率以及3周结石排净率比较差异无显著性（P＞0.05），但对照组术后总并发症发生率高于试验组，差异具有显著性（χ2=4.371,P＜0.05）。 结论　输尿管镜碎石术中使用阿托品注射液可以缓解输尿管痉挛，显著提高进镜成功率，虽然不能减少输尿管黏膜损伤、穿孔、输尿管抱镜等单项并发症的发生率，但是可以减少术中总并发症的发生率。<br>Abstract：Objective　To investigate the effect of atropine injection in ureteroscopic treatment of lower ureteral calculi. Methods　A total of 106 patients with lower ureteral calculi who planned to undergo ureteroscopic lithotripsy from March 2016 to December 2017 were enrolled and randomly divided into experimental group with 53 patients and control group with 53 patients. The patients in the experimental group were given intramuscular injection of atropine 0.02 mg/kg at 20 minutes before the start of the surgery, and those in the control group did not receive atropine before surgery. The two groups were compared in terms of success rate of ureteroscope insertion and incidence rate of postoperative complications. Results　No adverse drug reactions were observed in the experimental group. There was a significant difference in the success rate of ureteroscope insertion between the two groups (χ2=4.417,P<0.05). There were no significant differences in the incidence rates of postoperative ureteral perforation, ureteral mucosal injury, and ureteroscope retention and the 3-week calculi discharge rate between the two groups (P>0.05), but the control group had a significantly higher incidence rate of total complications after surgery than the experimental group (χ2=4.371,P<0.05). Conclusion　The use of atropine injection in ureteroscopic lithotripsy can relieve ureteral spasm and significantly improve the success rate of ureteroscope insertion. Although it cannot reduce the incidence rates of single complications such as ureteral mucosal injury, perforation, and ureteroscope retention, it can reduce the incidence rate of total complications after surgery
%K 输尿管镜检查
%K 碎石术
%K 输尿管结石
%K 阿托品
%K 手术后并发症
%K 治疗结果<br>Ureteroscopy
%K Lithotripsy
%K Ureteral calculi
%K Atropine
%K Postoperative complications
%K Treatment outcome
%U http://jpmed.qdu.edu.cn/CN/10.13362/j.jpmed.201906021