%0 Journal Article
%T An Alkaloid from Indonesianandrsquo;s Marine Sponges <em>Xestospongia muta</em> as Anti-dormant Mycobacterium <em>Desulfovibrio desulfuricans</em>
%A Guntur Febrian Illahi
%A Khairunnisa
%A N
%A Rauzatul Sakinah
%A Syarifah Keumala
%A Viqqi Kurni
%A a Muhammad Razi
%J -
%D 2018
%X Isolation of secondary metabolite from Indonesian¡¯s Marine Sponges Clathria sp., Xestospongia muta, and Endectyon delaubenfelsi against mycobacterium Desulfovibrio desulfuricans was completed on May 2018. Bioactive metabolites isolated based on bioassay-guided separation with several step of chromatography. The result of bioactivity showed that Xestospongia muta sponge has MIC50 value=0,1 ¦̀g/mL, Clathria sp. has MIC50 value=0.3 ¦̀g/mL and Endectyon delaubenfelsi has MIC50 value=0.3 ¦̀g/mL. Interpretation of the FTIR spectrum from the Xestospongia muta sponge indicate the active-metabolite has an O-H functional group at 3435.56 cm-1 with a fingerprint region of a C-O functional group at 1342.24 cm-1. The active metabolite has a C-H methyl group at 2853.39 cm-1 and C-H methylene at 2769.64 cm-1 and a C¡ÔN imine group at 2365.28 cm-1 with fingerprint region of C-N imine functional group at 1637,27 cm-1. The Results of cytotoxic show that MIC50 value of Xestospongia muta has potential activity as the new model to the drug discovery against mycobacterium Desulfovibrio desulfuricans
%K Nanda Muhammad Razi
%K Syarifah Keumala
%K Guntur Febrian Illahi
%K Rauzatul Sakinah
%K Khairunnisa
%K Viqqi Kurnianda
%K Desulfovibrio desulfuricans
%K Xestospongia muta
%K anti-dormant
%K alkaloid
%U https://www.imedpub.com/abstract/an-alkaloid-from-indonesianrsquos-marine-sponges-emxestospongia-mutaem-as-antidormant-mycobacterium-emdesulfovibrio-desulfuricansem-23542.html