%0 Journal Article
%T The Effects of Hepatic Ischemia-Reperfusion Injury on Postoperative Cognitive Function in Elderly Patients
%A Lina Hao
%A Pei Gao
%A Yiqiao Wang
%A Yuanhai Li
%A Zhenhua Ren
%J -
%D 2017
%X Background: Surgical trauma, such as hepatic ischemiareperfusion (HIR), resulting in the release of peripheral pro-inflammatory cytokines into the brain to affect neurocognitive function, is a prominent risk factor for the development of postoperative cognitive dysfunction (POCD). Methods: Forty patients of partial hepatectomy were divided into two groups: hepatic ischemia-reperfusion group (Group I/R) and control group (Group C). Each group had 20 individuals. Hepatic portal was clamped in the process of partial hepatectomy in the patients of Group I/R, otherwise in the Group C did not block Hepatic portal. Blood sample was collected on the 1th day before surgery and 4th days after surgery respectively, and then the contents of IL-6, TNF-¦Á, S100¦Â protein, AST and ALT were detected by ELISA kit. Neuropsychological tests were performed according Murkin¡¯s standard on the 1th day before surgery and the 4th day, and Z score was counted and used to identify the occurrence of POCD. Result: On the 4th days after surgery, the serum level of IL-6, TNF-¦Á and S100¦Â in the Group I/R patients significantly increased comparing with Group C (P<0.05). Psychological evaluation was performed, and found that Z score was more than 1.96 in 4 patients among Group C, while there were 11 patients in Group I/R. The incidences of POCD in Group I/R were 55%, and obviously higher than 16% in Group C. The incidence of POCD was correlated with serum levels of IL-6, TNF-¦Á and S100¦Â in Group I/R patients. Conclusion: Our results demonstrated that hepatic ischemia-reperfusion in the partial hepatectomy increased the incidence of POCD in elder patients, which was correlated with the elevated levels of IL-6, TNF-¦Á and S100¦Â in peripheral blood.
%K Elderly patients
%K Hepatic Ischemiareperfusion
%K Inflammatory factor
%K POCD
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/the-effects-of-hepatic-ischemiareperfusion-injury-on-postoperative-cognitive-function-in-elderly-patients.php?aid=17970