%0 Journal Article
%T The effects of Escherichia coli 0157: H7 lipopolysaccharide(LPS) from human, cattle and poultry isolates on haematological parameters of neonatal albino rats
%A Ekpo E. Antai
%A Emmanuel M. Ikpeme
%A James Epoke
%A Joseph F. Nfongeh
%A Lawrence B. Etim
%A Martin Akeh
%A Solomon E. Ekpiken
%J -
%D 2014
%X The response of some haematological parameters in neonatal albino rats to different filtrate dosages of cell free
  extracts of Escherichia coli 0157:H7 obtained from human, cattle and chicken sources were investigated. At higher
  levels of extracts administration [1.0ml and 2.0ml], Packed cell volume [PCV], Haemoglobin count [HBC] and Red
  Blood cell Count [RBC] had highest decrease with human faeces isolates [IHF] from 49.9 to 48.0%, 12.0-10.4g dl-1 and 7.7 to 7.6 x 109 ml-1 respectively. White Blood count [WBC], Erythrocytes sedimentation Rate [ESR),
  Lymphocytes and Neutrophils counts on the other hand had highest increase with cattle isolates [ICT] ranging from
  4.0 to 8.2 x 106 ml-1, 3.0 to 6.0x106 ml-1, 2.20 to 3.80 x 106 ml-1 and 1.60 to 3.90 x 106 ml-1 respectively. Statistical
  analysis showed significant difference [P<0.05] in the effects of the filtrate dosages on neutrophils and PCV in all
  the isolates. Significant difference [p<0.05] on the effects of the various dosages of human isolates [IHF] poultry
  [IPB] and cattle [ICT] isolates on both WBC and ESR were also observed . However, no significant difference was
  observed [P>0.05] with regards to the general effects of isolates on the haematological parameters studied. Cell
  free extracts of E. coli 0157:H7 used were found to have an overall negative effect on the haematological indices.
  Albino rats can therefore be recommended for use as a reliable small animal model to study host early responses as
  well as the role of bacterial virulence factors in the induction of haematological diseases
%K H7
%K Lipopolysaccharide
%K haematological parameters
%K disease
%K neonatal rats
%K list of open access journals
%K open access
%K open access journals
%K open access publication
%K open access publisher
%K open access publishing
%K open access journal articles
%K imedpub
%K imedpub publishing
%K insight medical publishing
%K imedpub online
%U https://www.imedpub.com/articles/the-effects-of-escherichia-coli-0157-h7-lipopolysaccharidelps-from-human-cattle-and-poultry-isolates-on-haematological-parameters.php?aid=16248