%0 Journal Article
%T Preventive Treatment with Diclofenac Suppositories May Improve BCG
Induced Cystitis Symptoms without Affecting Its Oncologic Efficacy: A
Prospective Double Blind Randomized Trial
%A Boris Friedman
%A Gal Rinott Mizrahi
%A Yael Hod
%A Yoram Dekel
%A Yuval Freifeld
%J -
%D 2017
%X Purpose: To evaluate whether prophylactic treatment with Diclofenac suppositories may relief bladder irritative symptoms following BCG irrigation, and to assess its effect on the oncologic outcome.
Methods: A prospective, randomized, double-blind, placebo-control trial on 36 patients diagnosed with Non- Muscle Invasive Bladder Cancer (NMIBC) treated with induction installations of BCG. Patients received either a transrectal Diclofenac suppository (50 mg) or a placebo suppository immediately prior to and 24 hours after bladder irrigation.
Following each irrigation patients completed a Quality of Life and a specific side effect questionnaire. Patients were thereafter followed prospectively for tumor recurrence.
Results: For each irrigation, patients in the treatment group had statistically significant lower complains of dysuria (presented as the percent change from baseline; 473% vs. 161% in the control and treatment groups respectively, p=0.026). Other BCG side effects affected by the suppositories are reported. During a mean follow up of 22.8 month, 56% and 58% of patients in the treatment and control groups respectively had tumor recurrence (p=0.96). No significant side effects have been observed related to the study drug.
Conclusion: Diclofenac suppositories are easy and safe to use and according to our results on this small study cohort, their use may suggest a beneficial effect in preventing complains caused by BCG induced cystitis without increasing tumor recurrence rate
%K Gal Rinott Mizrahi*
%K Avi Stein
%K Boris Friedman
%K Yuval Freifeld
%K Yael Hod
%K Yoram Dekel
%K Urinary bladder neoplasms
%K Immunotherapy
%K Diclofenac
%K Cystitis
%K Recurrence
%U https://www.imedpub.com/abstract/preventive-treatment-with-diclofenac-suppositories-may-improve-bcgrninduced-cystitis-symptoms-without-affecting-its-oncologic-efficacy-arnprospective-double-blind-randomized-trial-20476.html